Yes. Plugin-less communications are the only viable vision for browser-based communications going forward. Support for browser plugins is waning due to ongoing security & compatibility concerns. For example, Google & Mozilla are terminating support for the Netscape Plugin API and plugins in 2014[i] [ii]. For Internet Explorer 10 and 11, Microsoft has issued a statement of direction without plugins. In turn, plugin warnings will appear with every use unless in "enterprise mode" or "desktop mode". This points to a transition period to migrate Internet Explorer users off of plugins for future versions of Internet Explorer[iii]. In addition, plug-ins are not allowed on Chromebooks.
Today, Google Chrome, Mozilla Firefox and Opera all support real-time communications without a browser plugin. These three WebRTC browsers correlate to 1.2 billion endpoints today and by other estimates 63% of the browser market (via pageview market share at StatCounter) ...and growing.
[i] Lucian Constantin, “Google Chrome to block and banish plugins built using popular NPAPI architecture”, PC World, September 24, 2013 (http://www.pcworld.com/article/2049309/chrome-will-block-npapi-plugins-over-stability-security-concerns.html)
[ii] Zach Walton, “Firefox To Soon Block Plugins By Default”, WebProNews, September 25, 2013 (http://www.webpronews.com/firefox-to-soon-block-plugins-by-default-2013-09)
[iii] Internet Explorer Dev Center, “Get ready for plug-in free browsing” Microsoft Corporation (http://msdn.microsoft.com/en-us/library/ie/hh968248(v=vs.85).aspx)